Shepis got her start playing the part of Peter in James Gunn's first film Tromeo and Juliet. Shepis continued working in the genre she loved most, horror. Making several horror films a year, Shepis quickly became a fan favorite within the horror community in films such as Scarecrow, Syfy's Abominable the Sundance horror flick The Violent Kind and Syfy’s 12 Monkeys. Shepis most recently was part of the record breaking Sharknado 2, the horror comedy The Night Watchmen, the anthology Tales of Halloween and horror hit Deathcember. She also a voice actor for the Adult Swim TV show Robot Chicken and host of her own podcast Casualty Friday.